Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. It is typically
fatal within 2–5 years of symptom onset. The incidence of ALS is largely uniform across most …

Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons
degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of …

TAR DNA-binding protein 43 (TDP-43) is associated with a spectrum of neurodegenerative
diseases. Although TDP-43 resembles heterogeneous nuclear ribonucleoproteins, its RNA …

TAR deoxyribonucleic acid-binding protein 43 (TDP-43) is a multifunctional protein with
roles in transcription, pre-messenger ribonucleic acid (mRNA) splicing, mRNA stability and …

It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative
diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to …

The first reports of disorders that in terms of cognitive and behavioral symptoms resemble
frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic …

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that
preferentially targets motor neurons. It was recently found that dominant mutations in two …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly
understood clinical heterogeneity, underscored by significant differences in patient age at …