Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral
Fenton reaction for generating highly toxic hydroxyl free radicals (• OH) to achieve selective …

Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …

Most of the current nanoparticle‐based therapeutics worldwide failing in clinical trials face
three major challenges:(i) lack of an optimum drug delivery platform with precise …

Platinum drugs are commonly used in cancer therapy, but their therapeutic outcomes have
been significantly compromised by the drug resistance of cancer cells. To this end, intensive …

We report a novel multifunctional construct, M1, designed explicitly to target the DNA
damage response in cancer cells. M1 contains both a floxuridine (FUDR) and protein …

Purpose: To determine the relationship between resistance to chemotherapy and microRNA
(miRNA) expression in esophageal cancer, we focused on miRNAs known to be associated …

The serine/threonine phosphatase PP2A regulates a vast portion of the phosphoproteome
including pathways involved in apoptosis, proliferation and DNA damage response and …

Multiple molecular, cellular, micro-environmental and systemic causes of anticancer drug
resistance have been identified during the last 25 years. At the same time, genome-wide …

B cell activation during normal immune responses and oncogenic transformation impose
increased metabolic demands on B cells and their ability to retain redox homeostasis. While …