Targeting p53 pathways: mechanisms, structures, and advances in therapy
H Wang, M Guo, H Wei, Y Chen - Signal transduction and targeted …, 2023 - nature.com
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …
been a major focus of oncology research. The p53 protein is a transcription factor that can …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
L Palanikumar, L Karpauskaite, M Al-Sayegh… - Nature …, 2021 - nature.com
Missense mutations in p53 are severely deleterious and occur in over 50% of all human
cancers. The majority of these mutations are located in the inherently unstable DNA-binding …
cancers. The majority of these mutations are located in the inherently unstable DNA-binding …
p53 amyloid aggregation in cancer: function, mechanism, and therapy
J Li, M Guo, L Chen, Z Chen, Y Fu, Y Chen - Experimental Hematology & …, 2022 - Springer
Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …
been proposed in recent years. p53, the most well-known tumor suppressor, has been …
Therapeutic potential of foldamers: from chemical biology tools to drug candidates?
Over the past decade, foldamers have progressively emerged as useful architectures to
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …
The β-cell assassin: IAPP cytotoxicity
Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …
Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin
PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials.
Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product …
Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product …
Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics
CS Swenson, G Mandava, DM Thomas… - Chemical …, 2024 - ACS Publications
The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …
therapeutics is a central focus of chemical biology and therapeutic development. However, a …
[HTML][HTML] An investigation into the potential action of polyphenols against human Islet Amyloid Polypeptide aggregation in type 2 diabetes
Abstract Type 2 diabetes (T2D), a chronic metabolic disease characterized by
hyperglycemia, results in significant disease burden and financial costs globally. Whilst the …
hyperglycemia, results in significant disease burden and financial costs globally. Whilst the …
p53 and zinc: a malleable relationship
JH Ha, O Prela, DR Carpizo, SN Loh - Frontiers in Molecular …, 2022 - frontiersin.org
A large percentage of transcription factors require zinc to bind DNA. In this review, we
discuss what makes p53 unique among zinc-dependent transcription factors. The …
discuss what makes p53 unique among zinc-dependent transcription factors. The …