Structure, function and biology of tissue factor pathway inhibitor-2

HS Chand, DC Foster, W Kisiel - Thrombosis and haemostasis, 2005 - thieme-connect.com
Tissue factor pathway inhibitor-2 (TFPI-2) is a 32 kDa matrix-associated Kunitz-type serine
proteinase inhibitor consisting of a short amino-terminal region, three tandem Kunitz-type …

The role of tissue factor pathway inhibitor-2 in cancer biology

E Sierko, MZ Wojtukiewicz… - Seminars in thrombosis …, 2007 - thieme-connect.com
Tissue factor pathway inhibitor-2 (TFPI-2), a member of the Kunitz-type serine proteinase
inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). The …

Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry

W Ruf, EA Seftor, RJ Petrovan, RM Weiss, LM Gruman… - Cancer research, 2003 - AACR
Vasculogenic mimicry (VM), the formation of matrix-rich vascular-like networks in three-
dimensional culture corresponding with the expression of vascular cell-associated genes …

Tissue factor and angiogenesis in cancer

PM Fernandez, FR Rickles - Current Opinion in Hematology, 2002 - journals.lww.com
Idiopathic thrombosis often precedes the diagnosis of occult cancer by several years.
Whether hypercoagulability predisposes for malignancy or the converse holds true is an …

Tissue factor and tissue factor pathway inhibitor levels in trophoblast cells: implications for placental hemostasis

A Aharon, B Brenner, T Katz, Y Miyagi… - Thrombosis and …, 2004 - thieme-connect.com
The placenta is a highly vascularized organ with fetal and maternal blood supply.
Syncytiotrophoblasts (STB), which line the placenta villous are possibly involved in local …

Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion

SS Lakka, M Rajan, C Gondi, N Yanamandra… - Oncogene, 2002 - nature.com
Abstract Matrix metalloproteinase 9 (MMP-9) is known to play a major role in cell migration
and invasion in both physiological and pathological processes. Our previous work has …

CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion

N Bretz, A Noske, S Keller, N Erbe-Hofmann… - Clinical & experimental …, 2012 - Springer
CD24 is a glycosyl-phosphatidylinositol-anchored protein with mucin-type structure that
resides exclusively in membrane microdomains. CD24 is often highly expressed in …

[HTML][HTML] Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer

J Rollin, S Iochmann, C Blechet, F Hube… - British journal of …, 2005 - nature.com
Tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor that
inhibits plasmin-dependent activation of several metalloproteinases. Downregulation of TFPI …

Immunohistochemical localization of tissue factor pathway inhibitor-2 in human tumor tissue

MZ Wojtukiewicz, E Sierko, L Zimnoch… - Thrombosis and …, 2003 - thieme-connect.com
The progression of neoplasms is frequently associated with thromboembolic complications.
Coagulation proteins, particularly tissue factor (TF), have been shown to play a role in tumor …

A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in human glioma invasion

SD Konduri, CN Rao, N Chandrasekar, A Tasiou… - Oncogene, 2001 - nature.com
Human tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type serine protease inhibitor
that inhibits plasmin, trypsin, chymotrypsin, cathepsin G, and plasma kallikrein but not …