Immune response following traumatic spinal cord injury: Pathophysiology and therapies
RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …
significant loss of function and/or permanent disability. The pathophysiology of SCI is …
Stem cells in human neurodegenerative disorders—time for clinical translation?
O Lindvall, Z Kokaia - The Journal of clinical investigation, 2010 - Am Soc Clin Investig
Stem cell–based approaches have received much hype as potential treatments for
neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in …
neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in …
Clinical trials for stem cell therapies
A Trounson, RG Thakar, G Lomax, D Gibbons - BMC medicine, 2011 - Springer
In recent years, clinical trials with stem cells have taken the emerging field in many new
directions. While numerous teams continue to refine and expand the role of bone marrow …
directions. While numerous teams continue to refine and expand the role of bone marrow …
Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential
BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …
Clinical trials of stem cell treatment for spinal cord injury
K Yamazaki, M Kawabori, T Seki, K Houkin - International Journal of …, 2020 - mdpi.com
There are more than one million patients worldwide suffering paralysis caused by spinal
cord injury (SCI). SCI causes severe socioeconomic problems not only to the patients and …
cord injury (SCI). SCI causes severe socioeconomic problems not only to the patients and …
Clinical study of NeuroRegen scaffold combined with human mesenchymal stem cells for the repair of chronic complete spinal cord injury
Y Zhao, F Tang, Z Xiao, G Han, N Wang… - Cell …, 2017 - journals.sagepub.com
Regeneration of damaged neurons and recovery of sensation and motor function after
complete spinal cord injury (SCI) are challenging. We previously developed a collagen …
complete spinal cord injury (SCI) are challenging. We previously developed a collagen …
Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
Significant progress has been made during the past decade towards the clinical adoption of
cell-based therapeutics. However, existing cell-delivery approaches have shown limited …
cell-based therapeutics. However, existing cell-delivery approaches have shown limited …
Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients
S Karamouzian, SN Nematollahi-Mahani… - Clinical neurology and …, 2012 - Elsevier
BACKGROUND: In recent years, some studies were conducted to evaluate the effects of
stem cells from different sources on patients with spinal cord injury (SCI). This study was …
stem cells from different sources on patients with spinal cord injury (SCI). This study was …
Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells
SM Chacko, S Ahmed, K Selvendiran… - … of Physiology-Cell …, 2010 - journals.physiology.org
Stem cells transplanted to the ischemic myocardium usually encounter massive cell death
within a few days of therapy. Hypoxic preconditioning (HPC) is currently employed as a …
within a few days of therapy. Hypoxic preconditioning (HPC) is currently employed as a …
Long-term results of spinal cord injury therapy using mesenchymal stem cells derived from bone marrow in humans
JH Park, DY Kim, IY Sung, GH Choi, MH Jeon… - …, 2012 - journals.lww.com
BACKGROUND: Although the transplantation of mesenchymal stem cells (MSCs) after
spinal cord injury (SCI) has shown promising results in animals, less is known about the …
spinal cord injury (SCI) has shown promising results in animals, less is known about the …