Early-Onset Colorectal Cancer Early-onset disease (at< 50 years of age) accounts for 10%
of colorectal cancer cases, and the incidence is increasing, particularly in high-income …

Genomic tests expand diagnostic and screening opportunities but also identify genetic
variants of uncertain clinical significance (VUSs). Only a minority of VUSs are likely to prove …

In 2023, the NCCN Guidelines for Hepatobiliary Cancers were divided into 2 separate
guidelines: Hepatocellular Carcinoma and Biliary Tract Cancers. The NCCN Guidelines for …

Importance Germline testing guidelines are suggested for specific disease types or a family
history of cancer, yet alterations are found in cancer types in which germline testing is not …

Background & Aims Hereditary factors play a role in the development of colorectal cancer
(CRC). Identification of germline predisposition can have implications on treatment and …

PURPOSE Hereditary cancer syndromes infer high cancer risks and require intensive
surveillance. Identification of high-risk individuals among patients with colorectal cancer …

The last decade has seen rapid progress in the use of genomic tests, including gene panels,
whole‐exome sequencing, and whole‐genome sequencing, in research and clinical cancer …

Historically, professional society guidelines have recommended limited genetic testing for
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …

Cancer is a genomic disease in that gene alterations drive the cellular growth and immune
surveillance perturbations that enable malignant cells to take hold and to metastasize …

Background Germline variant evaluation in precision oncology opens new paths toward the
identification of patients with genetic tumor risk syndromes and the exploration of therapeutic …