The clinical use of deep brain stimulation (DBS) is among the most important advances in
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …

Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

Background Deep brain stimulation (DBS) of the subcallosal cingulate white matter has
shown promise as an intervention for patients with chronic, unremitting depression. To test …

Depression is associated with social risk factors, social impairments and poor social
functioning. This paper gives an overview of these social aspects using the NIMH Research …

Intuition suggests that perception follows sensation and therefore bodily feelings originate in
the body. However, recent evidence goes against this logic: interoceptive experience may …

Pleasure is mediated by well-developed mesocorticolimbic circuitry and serves adaptive
functions. In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affect) …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …

In this paper, we integrate recent theoretical and empirical developments in predictive
coding and active inference accounts of interoception (including the Embodied Predictive …