Regular or frequent use of analgesics and acute antimigraine drugs can increase the
frequency of headache, and induce the transition from episodic to chronic headache or …

Medication-overuse headache (MOH) is defined by the International Classification of
Headache Disorders as a headache in patients with a pre-existing primary headache …

The phenomena of habituation and sensitization are considered most useful for studying the
neuronal substrates of information processing in the CNS. Both were studied in primary …

Abnormalities in the simplest form of learning, habituation, have been reported in a variety of
neuropsychiatric disorders as etiologically diverse as Autism Spectrum Disorder, Fragile X …

The pathogenesis of medication overuse headache is unclear. Clinical and preclinical
studies have consistently demonstrated increased excitability of neurons in the cerebral …

Background The frequent or regular use of analgesics and anti-migraine drugs can make
headache more frequent and induce the transformation of episodic to chronic headache …

Among painful disorders, migraine is distinguishable by its chronic pathology and episodic
clinical manifestation. Only a small percentage of patients with migraine progress to a …

Background It is unclear whether cortical hyperexcitability in chronic migraine with
medication overuse headache (CM-MOH) is due to increased thalamocortical drive or …

Background: It is well-known that both inter-and intra-individual differences exist in the
perception of pain; this is especially true in migraine, an elusive pain disorder of the head …

In this review, the latest insights into habituation to pain in chronic pain are summarized.
Using a systematic search, results of studies on the evidence of habituation to …