The linkage of cells to their microenvironment is mediated by a series of bonds that
dynamically engage and disengage, in what has been conceptualized as the molecular …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

The widespread misuse of drugs has increased the number of multiresistant bacteria, and
this means that tools that can rapidly detect and characterize bacterial response to …

The leading front of a collectively migrating epithelium often destabilizes into multicellular
migration fingers where a cell initially similar to the others becomes a leader cell while its …

Adherent cells, crawling slugs, peeling paint, sessile liquid drops, bearings and many other
living and non-living systems apply forces to solid substrates. Traction force microscopy …

Many essential cellular functions in health and disease are closely linked to the ability of
cells to respond to mechanical forces. In the context of cell adhesion to the extracellular …

Cells generate mechanical forces (traction forces, TFs) while interacting with the
extracellular matrix or neighbouring cells. Forces are generated by both cells and …

Keratocytes are fast-moving cells in which adhesion dynamics are tightly coupled to the
actin polymerization motor that drives migration, resulting in highly coordinated cell …