• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The microbiology, epidemiology, diagnostics, and treatment of infective endocarditis (IE)
have changed significantly since the Duke Criteria were published in 1994 and modified in …

Background—Infective endocarditis is a potentially lethal disease that has undergone major
changes in both host and pathogen. The epidemiology of infective endocarditis has become …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

The content of these European Society of Cardiology (ESC) Guidelines has been published
for personal and educational use only. No commercial use is authorized. No part of the ESC …

Infective endocarditis is life-threatening; identification of the underlying etiology informs
optimized individual patient management. Changing epidemiology, advances in blood …

JCS 2017 Guideline on Prevention and Treatment of Infective Endocarditis Toggle navigation
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The role of surgery in active IE has expanded progressively since early reports of successful
outcome. 10 Subsequent declines in mortality may be attributed to a variety of improvements …

Background: The clinical profile and outcome of nosocomial and non-nosocomial health
care–associated native valve endocarditis are not well defined. Objective: To compare the …

Acute infective endocarditis is a complex disease with changing epidemiology and a rapidly
evolving knowledge base. To consistently achieve optimal outcomes in the management of …