Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

SB Sindher, A Long, AR Chin, A Hy, V Sampath… - Allergy, 2022 - Wiley Online Library
The incidence of food allergy (FA) has continued to rise over the last several decades,
posing significant burdens on health and quality of life. Significant strides into the …

Probiotics and gut microbiota: Mechanistic insights into gut immune homeostasis through TLR pathway regulation

H Kaur, SA Ali - Food & Function, 2022 - pubs.rsc.org
Consumption of probiotics as a useful functional food improves the host's wellbeing, and,
when paired with prebiotics (indigestible dietary fibre/carbohydrate), often benefits the host …

Paneth cells as the cornerstones of intestinal and organismal health: a primer

C Wallaeys, N Garcia‐Gonzalez… - EMBO Molecular Medicine, 2023 - embopress.org
Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small
intestine. In normal conditions, they function as the cornerstones of intestinal health by …

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity

EM Eshleman, T Rice, C Potter, A Waddell… - Immunity, 2024 - cell.com
Tuft cells in mucosal tissues are key regulators of type 2 immunity. Here, we examined the
impact of the microbiota on tuft cell biology in the intestine. Succinate induction of tuft cells …

[HTML][HTML] Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes

C Moschandrea, V Kondylis, I Evangelakos, M Herholz… - Nature, 2024 - nature.com
Digested dietary fats are taken up by enterocytes where they are assembled into pre-
chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation …

A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?

LS Hohman, LC Osborne - Aging Cell, 2022 - Wiley Online Library
Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against
the microbiota, as well as a conduit for signaling between the microbiota and systemic host …

Nutraceuticals prepared with specific strains of probiotics for supplementing gut microbiota in hosts allergic to certain foods or their additives

D Dahiya, PS Nigam - Nutrients, 2023 - mdpi.com
Certain nutrients cause discomfort, sensitivity reaction, and an intolerance for certain foods
or their ingredients when ingested by some consumers. Food reactions and gut …

Critical features of an in vitro intestinal absorption model to study the first key aspects underlying food allergen sensitization

W Dijk, C Villa, S Benedé… - … Reviews in Food …, 2023 - Wiley Online Library
New types of protein sources will enter our diet in a near future, reinforcing the need for a
straightforward in vitro (cell‐based) screening model to test and predict the safety of these …

Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7

Y Xiao, H Lian, XS Zhong… - Frontiers in …, 2022 - frontiersin.org
Background Previous studies implicated matrix metalloproteinases (MMPs), such as MMP-7,
in inflammatory bowel diseases (IBD) by showing increased activity during inflammation of …

Homeostasis and dysbiosis of the intestinal microbiota: comparing hallmarks of a healthy state with changes in inflammatory bowel disease

J Talapko, A Včev, T Meštrović, E Pustijanac, M Jukić… - Microorganisms, 2022 - mdpi.com
The gut microbiota, which represent a community of different microorganisms in the human
intestinal tract, are crucial to preserving human health by participating in various …