With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …

The senescence accelerated mouse (SAMP8) is a spontaneous animal model of
overproduction of amyloid precursor protein (APP) and oxidative damage. It develops early …

Alzheimer's disease (AD) is rarely addressed in the context of aging even though there is an
overlap in pathology. We previously used a phenotypic screening platform based on old age …

Current mouse models of Alzheimer's disease (AD) are restricted to the expression of AD-
related pathology associated with specific mutations present in early-onset familial AD and …

Oxidative stress plays an essential role in triggering many cellular processes including
programmed cell death. Proving a relationship between apoptosis and reactive oxygen …

Alzheimer's disease (AD) is a widespread and devastating progressive neurodegenerative
disease. Disease-modifying treatments remain beyond reach, and the etiology of the …

Melatonin is an endogenous pleiotropic molecule which orchestrates regulatory functions
and protective capacity against age‐related ailments. The increase in circulating levels of …

Epigenetics is emerging as the missing link among genetic inheritance, environmental
influences, and body and brain health status. In the brain, specific changes in nucleic acids …