Cancer is a multifactor and multistep process that is affected intrinsically by the genetic and
epigenetic makeup of tumor cells and extrinsically by the host microenvironment and …

Syntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1
(PDZ) domains, participating in multiple signaling pathways and modulating cellular …

Purpose: Liquid biopsy has great potential to improve the management of brain tumor
patients at high risk of surgery-associated complications. Here, the aim was to explore …

Glioma stem cells (GSCs) comprise a small subpopulation of glioblastoma multiforme cells
that contribute to therapy resistance, poor prognosis, and tumor recurrence. Protective …

Glioblastoma multiforme (GBM) is an intractable tumor despite therapeutic advances,
principally because of its invasive properties. Radiation is a staple in therapeutic regimens …

Background Malignant glioma is an aggressive cancer requiring new therapeutic targets.
MicroRNAs (miRNAs) regulate gene expression post transcriptionally and are implicated in …

Syntenin, a tandem PDZ domain containing scaffold protein, functions as a positive regulator
of cancer cell progression in several human cancers. We report here that syntenin positively …

The primary cause of cancer-related death from solid tumors is metastasis. While unraveling
the mechanisms of this complicated process continues, our ability to effectively target and …

Glioblastoma multiforme (GBM) is an aggressive cancer without currently effective therapies.
Radiation and temozolomide (radio/TMZ) resistance are major contributors to cancer …

The interaction between proteins is a fundamental event for cellular life that is generally
mediated by specialized protein domains or modules. PDZ domains are the largest class of …