The endoplasmic reticulum (ER) is the site of membrane protein insertion, folding, and
assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical …

Multipass membrane proteins contain two or more α-helical transmembrane domains
(TMDs) that span the lipid bilayer. They are inserted cotranslationally into the prokaryotic …

Mammals encode∼ 5,000 integral membrane proteins that need to be inserted in a defined
topology at the endoplasmic reticulum (ER) membrane by mechanisms that are incompletely …

The protein translocon at the endoplasmic reticulum comprises the Sec61 translocation
channel and numerous accessory factors that collectively facilitate the biogenesis of …

The heterotrimeric Sec61 complex is a major site for the biogenesis of transmembrane
proteins (TMPs), accepting nascent TMP precursors that are targeted to the endoplasmic …

Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a
Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin …

Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with
single-digit nanomolar potency. However, its biological and pharmacological properties …

Ten years ago, high-throughput genetic interaction analyses revealed an abundant and
widely conserved protein complex residing in the endoplasmic reticulum (ER) membrane …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

The Sec61 complex is the major protein translocation channel of the endoplasmic reticulum
(ER), where it plays a central role in the biogenesis of membrane and secretory proteins …