Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase and found to belong to the AGC family of serine/threonine …

The excessive activation of the renin-angiotensin system in kidney disease leads to
alteration of intracellular pathways which concur altogether to the induction of …

The high prevalence of cardiovascular disease in patients with chronic kidney disease
indicates significant interactions between pathogenic pathways operating in the kidney and …

Two human genetic tubulopathies, Bartter's (BS) and Gitelman's (GS) syndromes, have
normo/hypotension and absent cardiac remodeling despite their apparent angiotensin …

Among the complex mechanisms of AF pathogenesis, intracellular calcium overload and
oxidative stress play a major role, both triggered by inflammatory processes. The additional …

Background Pulmonary arterial hypertension (PAH) is a disease characterized by
pulmonary vascular remodeling that triggers fibrosis and excessive myocardium apoptosis …

Introduction Gitelman's syndrome (GS) is a rare inherited tubulopathy characterized by
hypokalemia, hypomagnesemia, and metabolic alkalosis due to inactivating mutations of the …

Connexins (Cxs) are transmembrane proteins that assemble into gap junction channels
(GJCs) and hemichannels (HCs). Previous research supports the involvement of Rho …