▪ Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene
expression plays a crucial role in the control of the immune response. A major breakthrough …

MHC class II molecules are expressed on the surface of antigen presenting cells and are
loaded with peptides processed from the phagosomal compartment of these cells. Such …

Regulation of MHC class II gene expression is an essential aspect of the control of the
immune response. Primary MHC class II deficiency is a genetically heterogeneous disease …

The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I
expression are tightly controlled at the transcriptional level. In this study, it is shown that the …

The X2 box of MHC class II promoters is homologous to TRE/CRE elements and is required
for expression of MHC class II genes. The X2 box-specific DNA binding activity, X2BP, was …

This review focuses on recent progress made in MHC regulation. The better characterization
of proteins that interact with MHC class I and II promoters and the isolation of genes …

Major histocompatibility complex (MHC) molecules serve as peptide receptors. These
peptides are derived from processed cellular or extra-cellular antigens. The MHC gene …

Transcription of major histocompatibility complex (MHC) class II genes is controlled largely
by the conserved promoter elements called the X and Y boxes. We show here that RFX, the …

The class II major histocompatibility complex (MHC) molecules function in the presentation
of processed peptides to helper T cells. As most mammalian cells can endocytose and …

Class II major histocompatibility complex (MHC) genes and the invariant (Ii) gene are
inducible by interferon-y (IFNy) but not by interferon-aand interferon-p. The promoter regions …