Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …

Molecular diagnostics has generated substantial dividends in dissecting the genetic basis of
myeloid neoplasms with eosinophilia. The family of diseases generated by dysregulated …

PURPOSE High allelic ratio (HAR) FLT3/ITD (AR> 0.4) mutations confer poor prognosis in
pediatric acute myeloid leukemia (AML). COG AAML1031 studied the feasibility and efficacy …

Despite major improvements in outcome over the past decades, acute myeloid leukemia
(AML) remains a life-threatening malignancy in children, with current survival rates of∼ …

Internal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in
30% of acute myeloid leukemias (AMLs) and confers a poor prognosis. Thirteen relapsed or …

Acute myeloid leukemia (AML) is a group of hematological diseases, phenotypic and
genetically heterogeneous, characterized by abnormal accumulation of blast cells in the …

Rapid technical advances in DNA sequencing and genome-wide association studies are
driving the discovery of the germline and somatic mutations that are present in different …

Bone cancers are characterised by the development of tumour cells in bone sites,
associated with a dysregulation of their environment. In the last two decades, numerous …

Acute myeloid leukemia (AML) is a heterogeneous disease caused by several gene
mutations and cytogenetic abnormalities affecting differentiation and proliferation of myeloid …