Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …

Background: The superiority of combination therapy for carbapenem-resistant Gram-
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …

Our objective was to examine the evidence of in vitro synergy of polymyxin-carbapenem
combination therapy against Gram-negative bacteria (GNB). A systematic review and meta …

Carbapenem-sparing strategies should be used, when feasible, for ESBL infections. The
majority of available nonrandomized studies highlight that combination for CRE seem to …

The emergence of resistant to carbapenems Gram-negative bacteria (CR GNB) has severely
challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to …

Currently, drug resistance, especially against cephalosporins and carbapenems, among
gram-negative bacteria is an important challenge, which is further enhanced by the limited …

The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated
the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin …

Abstract Purpose of Review The purpose of this review is to investigate the evolution and
epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and …

Testing for antimicrobial interactions has gained popularity in the last decade due to the
increasing prevalence of drug-resistant organisms and limited options for the treatment of …