How millions of axons navigate accurately toward synaptic targets during development is a
long-standing question. Over decades, multiple studies have enriched our understanding of …

The molecular mechanisms of neural circuit formation have been of interest to Santiago
Ramón y Cajal and thousands of neuroscientists sharing his passion for neural circuits ever …

The microenvironment of distant organ plays vital roles in regulating tumor metastases.
However, little is known about the crosstalk between metastasized tumor cells and target …

The mature nervous system relies on the polarized morphology of neurons for a directed
flow of information. These highly polarized cells use their somatodendritic domain to receive …

Proper innervation of peripheral organs helps to maintain physiological homeostasis and
elicit responses to external stimuli. Disruptions to normal function can result in …

The importance of cell adhesion molecules for the development of the nervous system has
been recognized many decades ago. Functional in vitro and in vivo studies demonstrated a …

Cell adhesion is tightly controlled in multicellular organisms, for example, through proteolytic
ectodomain shedding of the adhesion‐mediating cell surface transmembrane proteins. In …

Blood filtering by the kidney requires the establishment of an intricate vascular network that
functions to support body fluid and organ homeostasis. Despite these critical roles, little is …

During neural circuit formation, axons navigate from one intermediate target to the next, until
they reach their final target. At intermediate targets, axons switch from being attracted to …