Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …

Tumor cell migration is essential for invasion and dissemination from primary solid tumors
and for the establishment of lethal secondary metastases at distant organs. In vivo and in …

INTRODUCTION Cells migrate over long distances during normal embryonic development
and in disease, and they navigate through complex, branched paths. Chemotaxis, cell …

All epistemic agents physically consist of parts that must somehow comprise an integrated
cognitive self. Biological individuals consist of subunits (organs, cells, and molecular …

The directed migration of cell collectives is a driving force of embryogenesis,,. The
predominant view in the field is that cells in embryos navigate along pre-patterned …

Assay devices designed for these applications offer improvements to existing methods or
provide fundamentally new strategies. Both mature methods and novel techniques have …

Cell migration is a fundamental process that occurs during embryo development. Classic
studies using in vitro culture systems have been instrumental in dissecting the principles of …

During cancer cell invasion, faster moving cancer cells play a dominant role by invading
further and metastasizing earlier. Despite the importance of these outlier cells, the source of …

Microfluidic devices can better control cellular microenvironments compared to conventional
cell migration assays. Over the past few years, microfluidics-based chemotaxis studies …

Cells in the body are physically confined by neighboring cells, tissues, and the extracellular
matrix. Although physical confinement modulates intracellular signaling and the underlying …