Recent advances in mucoadhesive interface materials, mucoadhesion characterization, and technologies

IS Bayer - Advanced Materials Interfaces, 2022 - Wiley Online Library
Mucoadhesion is an extremely important field of adhesion science and the comprehensive
understanding and modulation of mucoadhesion can lead to lifesaving materials and …

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

JS Suk, Q Xu, N Kim, J Hanes, LM Ensign - Advanced drug delivery reviews, 2016 - Elsevier
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …

PEGylation for enhancing nanoparticle diffusion in mucus

JT Huckaby, SK Lai - Advanced drug delivery reviews, 2018 - Elsevier
The viscoelastic mucus secretions coating exposed organs such as the lung airways and the
female reproductive tract can trap and quickly eliminate not only foreign pathogens and …

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

Q Xu, LM Ensign, NJ Boylan, A Schon, X Gong… - ACS …, 2015 - ACS Publications
Achieving sustained drug delivery to mucosal surfaces is a major challenge due to the
presence of the protective mucus layer that serves to trap and rapidly remove foreign …

A holistic approach to targeting disease with polymeric nanoparticles

CJ Cheng, GT Tietjen, JK Saucier-Sawyer… - Nature reviews Drug …, 2015 - nature.com
The primary goal of nanomedicine is to improve clinical outcomes. To this end, targeted
nanoparticles are engineered to reduce non-productive distribution while improving …

Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review

A Sosnik, J das Neves, B Sarmento - Progress in Polymer Science, 2014 - Elsevier
The presence of a mucus layer that covers the surface of a variety of organs has been
capitalized to develop mucoadhesive dosage forms that remain in the administration site for …

Mucoadhesion: A promising approach in drug delivery system

S Mansuri, P Kesharwani, K Jain, RK Tekade… - Reactive and functional …, 2016 - Elsevier
Mucoadhesion, the state in which two materials, amongst which one is biological in nature,
adhere to each other for extended periods of time with the help of interfacial forces, provides …

Mucoadhesive and thermogelling systems for vaginal drug delivery

CM Caramella, S Rossi, F Ferrari, MC Bonferoni… - Advanced drug delivery …, 2015 - Elsevier
This review focuses on two formulation approaches, mucoadhesion and thermogelling,
intended for prolonging residence time on vaginal mucosa of medical devices or drug …

PEGylation: a promising strategy to overcome challenges to cancer-targeted nanomedicines: a review of challenges to clinical transition and promising resolution

Z Hussain, S Khan, M Imran, M Sohail… - Drug delivery and …, 2019 - Springer
On account of heterogeneity, intrinsic ability of drug resistance, and the potential to invade to
other parts of the body (malignancy), the development of a rational anticancer regimen is …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …