Cleft lip and/or cleft palate (CL/P) collectively are well known as being amongst the most
common birth defects but we still have difficulty explaining why the majority of cases occur …

CDH1 encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is
involved in major cellular processes such as embryogenesis and maintenance of tissue …

The loss of E-cadherin expression in association with the epithelial–mesenchymal transition
(EMT) occurs frequently during tumor metastasis. However, metastases often retain E …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer
(LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A …

A dozen genes/regions have been confirmed as genetic risk factors for oral clefts in human
association and linkage studies, and animal models argue even more genes may be …

Tooth agenesis and orofacial clefts represent the most common developmental anomalies
and their co-occurrence is often reported in patients as well in animal models. The aim of the …

Background & Aims Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1)
cause a predisposition to gastric cancer. We evaluated the ability of the internationally …

The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal.
Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about …

Purpose: Blepharocheilodontic (BCD) syndrome is a rare autosomal dominant condition
characterized by eyelid malformations, cleft lip/palate, and ectodermal dysplasia. The …