Small‐Molecule Quenchers for Förster Resonance Energy Transfer: Structure, Mechanism, and Applications
B Fang, Y Shen, B Peng, H Bai, L Wang… - Angewandte …, 2022 - Wiley Online Library
For fluorogenic probes, Förster resonance energy transfer (FRET) is one of the most widely
used mechanisms to realize the detection of biochemical activities. Dark quenchers relax …
used mechanisms to realize the detection of biochemical activities. Dark quenchers relax …
DNA-mediated homogeneous binding assays for nucleic acids and proteins
The detection of nucleic acids and proteins is fundamental for studying their functions and
for the development of molecular diagnostics. These molecules carry out most biological …
for the development of molecular diagnostics. These molecules carry out most biological …
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
S Schoors, U Bruning, R Missiaen, KCS Queiroz… - Nature, 2015 - nature.com
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here
we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO) …
we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO) …
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
DC Goldstone, V Ennis-Adeniran, JJ Hedden… - Nature, 2011 - nature.com
SAMHD1, an analogue of the murine interferon (IFN)-γ-induced gene Mg11 (ref.), has
recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that …
recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that …
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence
Oncogene-induced senescence is characterized by a stable cell growth arrest, thus
providing a tumor suppression mechanism. However, the underlying mechanisms for this …
providing a tumor suppression mechanism. However, the underlying mechanisms for this …
Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer
(TNBC), and strategies to circumvent resistance are required. Using in vitro and in vivo …
(TNBC), and strategies to circumvent resistance are required. Using in vitro and in vivo …
NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine
Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics,
their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside …
their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside …
SAMHD1‐dependent retroviral control and escape in mice
J Rehwinkel, J Maelfait, A Bridgeman, R Rigby… - The EMBO …, 2013 - embopress.org
SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV‐1) in cultured
human cells. SAMHD1 mutations cause autoimmune Aicardi‐Goutières syndrome and are …
human cells. SAMHD1 mutations cause autoimmune Aicardi‐Goutières syndrome and are …
ATM couples replication stress and metabolic reprogramming during cellular senescence
Replication stress induced by nucleotide deficiency plays an important role in cancer
initiation. Replication stress in primary cells typically activates the cellular senescence tumor …
initiation. Replication stress in primary cells typically activates the cellular senescence tumor …
SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation
J Wang, F Lu, XY Shen, Y Wu, L Zhao - Biochemical and biophysical …, 2014 - Elsevier
The function of dNTP hydrolase SAMHD1 as a viral restriction factor to inhibit the replication
of several viruses in human immune cells was well established. However, its regulation and …
of several viruses in human immune cells was well established. However, its regulation and …