The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …

Key discoveries in aging research have been made possible with the use of model
organisms. Caenorhabditis elegans is a short-lived nematode that has become a well …

Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular
function, transcription of proteasome subunit genes is induced in response to proteasome …

Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress
and aging. In a previous paper (Lehrbach and Ruvkun, 2016) we showed that the ER …

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome
function is vulnerable to environmental insults, cellular protein imbalance and targeted …

A protein's structure is determined by its amino acid sequence and post-translational
modifications, and provides the basis for its physiological functions. Across all organisms …

Neurodegenerative diseases are largely defined by protein aggregates in affected tissues.
Aggregates contain some shared components as well as proteins thought to be specific for …

Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in
cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells …

The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an
important role in the clearance of oxidant-damaged proteins under inflammatory and …

Background The proteasome catalyzes the degradation of many mis-folded proteins, which
are otherwise cytotoxic. There is interest in the discovery of proteasome agonists, but …