Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut
The gut microbiota regulates levels of serotonin (5-hydroxytryptamine (5-HT)) in the
intestinal epithelium and lumen,,,–. However, whether 5-HT plays a functional role in …
intestinal epithelium and lumen,,,–. However, whether 5-HT plays a functional role in …
Organic cation transporters in the lung—current and emerging (patho) physiological and pharmacological concepts
Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1
and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …
and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …
The vesicular monoamine transporter 2: an underexplored pharmacological target
Active transport of neurotransmitters into synaptic vesicles is required for their subsequent
exocytotic release. In the monoamine system, this process is carried out by the vesicular …
exocytotic release. In the monoamine system, this process is carried out by the vesicular …
Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse
NJ Clauss, FP Mayer, WA Owens, M Vitela… - Molecular …, 2023 - nature.com
Concurrent cocaine and alcohol use is among the most frequent drug combination, and
among the most dangerous in terms of deleterious outcomes. Cocaine increases …
among the most dangerous in terms of deleterious outcomes. Cocaine increases …
Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function
The concentrative power of the transporters for dopamine (DAT), norepinephrine (NET), and
serotonin (SERT) is thought to be fueled by the transmembrane Na+ gradient, but it is …
serotonin (SERT) is thought to be fueled by the transmembrane Na+ gradient, but it is …
Structure–Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: α-Pyrrolidinohexiophenone (α-PHP)
α-Pyrrolidinohexiophenone (α-PHP) is the one-carbon unit α-extended homolog of the better-
known and widely abused synthetic cathinone central stimulant α-PVP (“flakka”); both are …
known and widely abused synthetic cathinone central stimulant α-PVP (“flakka”); both are …
Differentiated HT22 cells as a novel model for in vitro screening of serotonin reuptake inhibitors
J Lim, Y Bang, KM Kim, HJ Choi - Frontiers in Pharmacology, 2023 - frontiersin.org
The mouse hippocampal neuronal cell line HT22 is frequently used as an in vitro model to
investigate the role of hippocampal cholinergic neurons in cognitive functions. HT22 cells …
investigate the role of hippocampal cholinergic neurons in cognitive functions. HT22 cells …
Evidence for PMAT- and OCT-like biogenic amine transporters in a probiotic strain of Lactobacillus: Implications for interkingdom communication within the microbiota …
M Lyte, DR Brown - PLoS One, 2018 - journals.plos.org
The ability of prokaryotic microbes to produce and respond to neurochemicals that are more
often associated with eukaryotic systems is increasingly recognized through the concept of …
often associated with eukaryotic systems is increasingly recognized through the concept of …
New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2)
G Hu, A Henke, RJ Karpowicz Jr… - ACS chemical …, 2013 - ACS Publications
Vesicular monoamine transporter 2 (VMAT2) is an essential component of the
monoaminergic neurotransmission system in the brain as it transports monoamine …
monoaminergic neurotransmission system in the brain as it transports monoamine …
Limosilactobacillus reuteri ATCC 6475 metabolites upregulate the serotonin transporter in the intestinal epithelium
The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the
availability of 5-HT within the intestine. In the absence of SERT, 5-HT remains in the …
availability of 5-HT within the intestine. In the absence of SERT, 5-HT remains in the …