Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation.
While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of …

Insect-derived baculoviruses have emerged as versatile and safe workhorses of
biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop …

Autoimmune/inflammatory diseases affect many people and are an important cause of
global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity …

Because of their immunomodulatory activities, human mesenchymal stem cells (hMSCs) are
being explored to treat a variety of chronic conditions such as inflammatory bowel disorders …

Repair of large calvarial bony defect remains a challenge for orthopedic surgeons. Since
microRNAs (miRNAs) modulate the osteogenesis of osteoprogenitor cells, we aimed to …

A significant number of clinical trials have been undertaken to explore the use of
mesenchymal stem cells (MSCs) for the treatment of several diseases such as Crohn's …

Gene therapy has converged with bone engineering over the past decade, by which a
variety of therapeutic genes have been delivered to stimulate bone repair. These genes can …

Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a
broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity …

Calvarial bone healing is difficult and grafts comprising adipose-derived stem cells (ASCs)
and PLGA (poly (lactic-co-glycolic acid)) scaffolds barely heal rabbit calvarial defects …

Background: The use of bone morphogenic protein and mesenchymal stem cells has shown
promise in promoting bone regeneration in calvarial defects. However, a systematic review …