Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging
and even more for extrinsic aging. Although the results are quite different in dermis and …

As a central hub of cellular metabolism and signaling, the mitochondrion is a crucial
organelle whose dysfunction can cause disease and whose activity is intimately connected …

Although a budding yeast culture can be propagated eternally, individual yeast cells age
and eventually die. The detailed knowledge of this unicellular eukaryotic species as well as …

Microbes have shown a remarkable ability in evading the killing actions of antimicrobial
agents, such that treatment of bacterial infections represents once more an urgent global …

Aconitase, an enzyme possessing an iron–sulfur cluster that is sensitive to oxidation, is
involved in the regulation of cellular metabolism. There are two isoenzymes of aconitase …

Fluorescence loss in photobleaching experiments and analysis of mitochondrial function
using superoxide and redox potential biosensors revealed that mitochondria within …

In proliferating cells, a transition from aerobic to anaerobic metabolism is known as the
Warburg effect, whose reversal inhibits cancer cell proliferation. Studying its regulator …

Mitochondria are responsible for generating adenosine triphosphate (ATP) and metabolic
intermediates for biosynthesis. These dual functions require the activity of the electron …

Eukaryotic cells can survive the loss of their mitochondrial genome, but consequently suffer
from severe growth defects.'Petite yeasts', characterized by mitochondrial genome loss, are …

Bacteria are thought to cope with fluctuating environmental solute concentrations primarily
by adjusting the osmolality of their cytoplasm. To obtain insights into the underlying …