The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

[HTML][HTML] Calcium signaling in Alzheimer's disease & therapies

BCK Tong, AJ Wu, M Li, KH Cheung - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer's disease protects against mitochondrial dysfunction and mitigates brain …

A Verma, A Shteinfer-Kuzmine, N Kamenetsky… - Translational …, 2022 - Springer
Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …

Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

NN Nalivaeva, AJ Turner - British journal of pharmacology, 2019 - Wiley Online Library
Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic
developments in Alzheimer's disease (AD) research for more than 25 years, yet no …

Regulation of human MAPT gene expression

ML Caillet-Boudin, L Buée, N Sergeant… - Molecular …, 2015 - Springer
The number of known pathologies involving deregulated Tau expression/metabolism is
increasing. Indeed, in addition to tauopathies, which comprise approximately 30 diseases …

A brief overview of amyloids and Alzheimer's disease

SY Ow, DE Dunstan - Protein Science, 2014 - Wiley Online Library
Amyloid fibrils are self‐assembled fibrous protein aggregates that are associated with a
number of presently incurable diseases such as Alzheimer's and Parkinson's disease …

Neprilysin and Aβ clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer's disease

MOW Grimm, J Mett, CP Stahlmann… - Frontiers in aging …, 2013 - frontiersin.org
One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …

MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced …

JM Long, B Ray, DK Lahiri - Journal of Biological Chemistry, 2014 - ASBMB
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ)
peptide as neuritic plaques in the brain. The short Aβ peptide is derived from the large …

Sevoflurane aggravates the progress of Alzheimer's disease through NLRP3/Caspase-1/Gasdermin D pathway

D Tian, Y Xing, W Gao, H Zhang, Y Song… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Alzheimer's disease (AD) is the most common form of dementia worldwide.
Previous studies have reported that sevoflurane, a frequently used anesthetic, can induce …

[HTML][HTML] P53 dysfunction in neurodegenerative diseases-the cause or effect of pathological changes?

A Szybińska, W Leśniak - Aging and disease, 2017 - ncbi.nlm.nih.gov
Neurodegenerative diseases are a heterogeneous, mostly age-associated group of
disorders characterized by progressive neuronal loss, the most prevalent being Alzheimer …