[HTML][HTML] Cellular mechanotransduction: from tension to function
F Martino, AR Perestrelo, V Vinarský, S Pagliari… - Frontiers in …, 2018 - frontiersin.org
Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
Y Gruenbaum, R Foisner - Annual review of biochemistry, 2015 - annualreviews.org
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
[HTML][HTML] Genomic analyses implicate noncoding de novo variants in congenital heart disease
A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …
[HTML][HTML] Mechanosensing and fibrosis
DJ Tschumperlin, G Ligresti… - The Journal of …, 2018 - Am Soc Clin Investig
Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …
The driving force: nuclear mechanotransduction in cellular function, fate, and disease
M Maurer, J Lammerding - Annual review of biomedical …, 2019 - annualreviews.org
Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …
Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …
pharmacological interventions that are associated with poor adherence and adverse effects …
[HTML][HTML] Nuclear mechanics and mechanotransduction in health and disease
P Isermann, J Lammerding - Current Biology, 2013 - cell.com
The nucleus is the defining feature of eukaryotic cells and often represents the largest
organelle. Over the past decade, it has become apparent that the nucleus is tightly …
organelle. Over the past decade, it has become apparent that the nucleus is tightly …
[HTML][HTML] When lamins go bad: nuclear structure and disease
KH Schreiber, BK Kennedy - Cell, 2013 - cell.com
Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …
group of phenotypically diverse genetic disorders known as laminopathies, which have …
Chemical inhibition of NAT10 corrects defects of laminopathic cells
Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause
misshapen nuclei and altered chromatin organization associated with cancer and …
misshapen nuclei and altered chromatin organization associated with cancer and …
Emery‐Dreifuss muscular dystrophy
SA Heller, R Shih, R Kalra, PB Kang - Muscle & nerve, 2020 - Wiley Online Library
Emery‐Dreifuss muscular dystrophy (EDMD) is a rare muscular dystrophy, but is particularly
important to diagnose due to frequent life‐threatening cardiac complications. EDMD …
important to diagnose due to frequent life‐threatening cardiac complications. EDMD …