From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Pharmacokinetics and pharmacodynamics of cannabinoids

F Grotenhermen - Clinical pharmacokinetics, 2003 - Springer
Abstract Δ 9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects
caused by the consumption of cannabis, both the marijuana-like action and the medicinal …

The endocannabinoid system as an emerging target of pharmacotherapy

P Pacher, S Bátkai, G Kunos - Pharmacological reviews, 2006 - ASPET
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures—a short review

I Svíženská, P Dubový, A Šulcová - Pharmacology Biochemistry and …, 2008 - Elsevier
In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …

Endocannabinoids and exercise

A Dietrich, WF McDaniel - British journal of sports medicine, 2004 - bjsm.bmj.com
Exercise induces changes in mental status, particularly analgesia, sedation, anxiolysis, and
a sense of wellbeing. The mechanisms underlying these changes remain unknown. Recent …

[HTML][HTML] Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic

E Aso, I Ferrer - Frontiers in pharmacology, 2014 - frontiersin.org
The limited effectiveness of current therapies against Alzheimer's disease (AD) highlights
the need for intensifying research efforts devoted to developing new agents for preventing or …

Cannabinoids and autoimmune diseases: A systematic review

V Katchan, P David, Y Shoenfeld - Autoimmunity reviews, 2016 - Elsevier
Cannabinoids have shown to have a variety effects on body systems. Through CB1 and CB2
receptors, amongst other, they exert an effect by modulating neurotransmitter and cytokine …

Evidence for novel cannabinoid receptors

M Begg, P Pacher, S Bátkai, D Osei-Hyiaman… - Pharmacology & …, 2005 - Elsevier
Cannabinoids, including the bioactive constituents of the marijuana plant, their synthetic
analogs, and endogenous lipids with cannabinoid-like activity, produce their biological …

Endogenous cannabinoid system as a modulator of food intake

D Cota, G Marsicano, B Lutz, V Vicennati… - International journal of …, 2003 - nature.com
The ability of Cannabis sativa (marijuana) to increase hunger has been noticed for
centuries, although intensive research on its molecular mode of action started only after the …

Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

S Bátkai, P Pacher, D Osei-Hyiaman, S Radaeva… - Circulation, 2004 - Am Heart Assoc
Background—Endocannabinoids are novel lipid mediators with hypotensive and
cardiodepressor activity. Here, we examined the possible role of the endocannabinergic …