From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
Pharmacokinetics and pharmacodynamics of cannabinoids
F Grotenhermen - Clinical pharmacokinetics, 2003 - Springer
Abstract Δ 9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects
caused by the consumption of cannabis, both the marijuana-like action and the medicinal …
caused by the consumption of cannabis, both the marijuana-like action and the medicinal …
The endocannabinoid system as an emerging target of pharmacotherapy
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …
triggered an exponential growth of studies exploring the endocannabinoid system and its …
Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures—a short review
I Svíženská, P Dubový, A Šulcová - Pharmacology Biochemistry and …, 2008 - Elsevier
In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …
Endocannabinoids and exercise
A Dietrich, WF McDaniel - British journal of sports medicine, 2004 - bjsm.bmj.com
Exercise induces changes in mental status, particularly analgesia, sedation, anxiolysis, and
a sense of wellbeing. The mechanisms underlying these changes remain unknown. Recent …
a sense of wellbeing. The mechanisms underlying these changes remain unknown. Recent …
[HTML][HTML] Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic
E Aso, I Ferrer - Frontiers in pharmacology, 2014 - frontiersin.org
The limited effectiveness of current therapies against Alzheimer's disease (AD) highlights
the need for intensifying research efforts devoted to developing new agents for preventing or …
the need for intensifying research efforts devoted to developing new agents for preventing or …
Cannabinoids and autoimmune diseases: A systematic review
V Katchan, P David, Y Shoenfeld - Autoimmunity reviews, 2016 - Elsevier
Cannabinoids have shown to have a variety effects on body systems. Through CB1 and CB2
receptors, amongst other, they exert an effect by modulating neurotransmitter and cytokine …
receptors, amongst other, they exert an effect by modulating neurotransmitter and cytokine …
Evidence for novel cannabinoid receptors
Cannabinoids, including the bioactive constituents of the marijuana plant, their synthetic
analogs, and endogenous lipids with cannabinoid-like activity, produce their biological …
analogs, and endogenous lipids with cannabinoid-like activity, produce their biological …
Endogenous cannabinoid system as a modulator of food intake
D Cota, G Marsicano, B Lutz, V Vicennati… - International journal of …, 2003 - nature.com
The ability of Cannabis sativa (marijuana) to increase hunger has been noticed for
centuries, although intensive research on its molecular mode of action started only after the …
centuries, although intensive research on its molecular mode of action started only after the …
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
Background—Endocannabinoids are novel lipid mediators with hypotensive and
cardiodepressor activity. Here, we examined the possible role of the endocannabinergic …
cardiodepressor activity. Here, we examined the possible role of the endocannabinergic …