The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …

Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …

Chromosome segregation, transcriptional regulation, and repair of DNA double-strand
breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes …

In eukaryotes, the process of sister chromatid cohesion holds the two sister chromatids (the
replicated chromosomes) together from DNA replication to the onset of chromosome …

Faithful chromosome segregation and repair of DNA double-strand breaks (DSBs) require
cohesin, the protein complex that mediates sister-chromatid cohesion. Cohesion between …

Cornelia de Lange syndrome (CdLS)(OMIM# 122470,# 300590 and# 610759) is a dominant
genetic disorder with multiple organ system abnormalities which is classically characterized …

Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes.
From yeast to humans, cell cycle progression and cell division require the activation of a …

Studies on budding yeast have exposed the highly conserved mechanisms by which
duplicated chromosomes are evenly distributed to daughter cells at the metaphase …

Cohesin is a four subunit complex, conserved from yeast to man, with the ability to hold
together two DNA segments within its ring-shaped structure. When the two segments belong …

Cornelia de Lange syndrome (CdLS) is genetically heterogeneous and is usually sporadic,
occurring approximately once per 10,000 births. CdLS individuals display diverse and …