Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in
a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and
unless the cause and consequences can be resolved, the pain will become chronic. As …

The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

A task group of the Science Committee of the Association for Palliative Medicine of Great
Britain and Ireland (APM) was convened to produce some up-to-date, evidence-based …

Cancer pain significantly affects the diagnosis, quality of life and survival of patients with
cancer. During the past decade, preclinical and clinical data has begun to provide insight …

Pain is the most disruptive influence on the quality of life of cancer patients. Although
significant advances are being made in cancer treatment and diagnosis, the basic …

The aim of this investigation was to determine whether murine models of inflammatory,
neuropathic and cancer pain are each characterized by a unique set of neurochemical …

The cancer-related event that is most disruptive to the cancer patient's quality of life is pain.
To begin to define the mechanisms that give rise to cancer pain, we examined the …

Bone cancer pain is common among cancer patients and can have a devastating effect on
their quality of life. A chief problem in designing new therapies for bone cancer pain is that it …