Protein S-palmitoylation, the covalent lipid modification of the side chain of Cys residues
with the 16-carbon fatty acid palmitate, is the most common acylation of proteins in …

Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …

G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete
understanding of how they signal through 16 non-visual G-protein signal transducers …

G protein-coupled receptors transduce diverse extracellular signals, such as
neurotransmitters, hormones, chemokines, and sensory stimuli, into intracellular responses …

Many receptors for neurotransmitters and hormones rely upon members of the Gqα family of
heterotrimeric G proteins to exert their actions on target cells. Gα subunits of the Gq class of …

G protein–coupled receptors (GPCRs) transmit signals by forming active-state complexes
with heterotrimeric G proteins. It has been suggested that some GPCRs also assemble with …

G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the
human genome. They are subject to numerous post-translational modifications, including …

Protein palmitoylation is the most common posttranslational lipid modification; its reversibility
mediates protein shuttling between intracellular compartments. A large family of DHHC (Asp …

Constitutively active G protein α subunits cause cancer, cholera, Sturge-Weber syndrome,
and other disorders. Therapeutic intervention by targeted inhibition of constitutively active …

Thrombin activates endothelial cell signaling by cleaving the protease-activated receptor-1
(PAR1). However, the function of the apparently nonsignaling receptor PAR3 also …