The biology and mathematical modelling of glioma invasion: a review

JCL Alfonso, K Talkenberger… - Journal of the …, 2017 - royalsocietypublishing.org
Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …

Necrotic reshaping of the glioma microenvironment drives disease progression

SM Markwell, JL Ross, CL Olson, DJ Brat - Acta Neuropathologica, 2022 - Springer
Glioblastoma is the most common primary brain tumor and has a dismal prognosis. The
development of central necrosis represents a tipping point in the evolution of these tumors …

Patch-based convolutional neural network for whole slide tissue image classification

L Hou, D Samaras, TM Kurc, Y Gao… - Proceedings of the …, 2016 - openaccess.thecvf.com
Abstract Convolutional Neural Networks (CNN) are state-of-the-art models for many image
classification tasks. However, to recognize cancer subtypes automatically, training a CNN on …

[HTML][HTML] The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma

LAD Cooper, DA Gutman, C Chisolm, C Appin… - The American journal of …, 2012 - Elsevier
The Cancer Genome Atlas (TCGA) project has generated gene expression data that divides
glioblastoma (GBM) into four transcriptional classes: proneural, neural, classical, and …

Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche

DW Infanger, YJ Cho, BS Lopez, S Mohanan, SC Liu… - Cancer research, 2013 - AACR
Glioblastoma multiforme contains a subpopulation of cancer stem–like cells (CSC) believed
to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs …

Molecular genetics of gliomas

CL Appin, DJ Brat - The Cancer Journal, 2014 - journals.lww.com
Diffusely infiltrating gliomas are the most common primary brain tumors and include
astrocytomas, oligodendrogliomas, and oligoastrocytomas of grades II and III and …

[HTML][HTML] PDA-based drug delivery nanosystems: a potential approach for glioma treatment

H Wu, M Wei, Y Xu, Y Li, X Zhai, P Su… - International journal …, 2022 - ncbi.nlm.nih.gov
Glioma is characterized by high mortality and low postoperative survival. Despite the
availability of various therapeutic approaches and molecular typing, the treatment failure …

Machine-based morphologic analysis of glioblastoma using whole-slide pathology images uncovers clinically relevant molecular correlates

J Kong, LAD Cooper, F Wang, J Gao, G Teodoro… - PloS one, 2013 - journals.plos.org
Pathologic review of tumor morphology in histologic sections is the traditional method for
cancer classification and grading, yet human review has limitations that can result in low …

Biomarker-driven diagnosis of diffuse gliomas

CL Appin, DJ Brat - Molecular aspects of medicine, 2015 - Elsevier
The diffuse gliomas are primary central nervous system tumors that arise most frequently in
the cerebral hemispheres of adults. They are currently classified as astrocytomas …

Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis

CL Appin, DJ Brat - Advances in anatomic pathology, 2015 - journals.lww.com
Gliomas are a large and diverse group of primary brain tumors that include those that are
diffusely infiltrative and others that are well-circumscribed and low grade. Diffuse gliomas …