Indazoles is an important class of heterocyclic compounds having a wide range of biological
and pharmaceutical applications. There is enormous potential in the synthesis of novel …

The human genome comprises more than 500 protein kinases including serine/threonine,
tyrosine and dual specificity kinases. 1, 2 Because of the important physiological and …

Cancer is one of the leading causes of human mortality globally; therefore, intensive efforts
have been made to seek new active drugs with improved anticancer efficacy. Indazole …

More than 500 compounds chosen to represent kinase inhibitor space have been screened
against a panel of over 200 protein kinases. Significant results include the identification of …

Great advances in elucidating molecular structures allow the precise determination of the
interactions between a protein and a therapeutic agent. Enzyme inhibitors are used as a …

The present invention relates to novel pyrimidine, pyrrolo pyrimidine, pyrrolo-pyridine,
pyridine, purine and triazine compounds which are able to modulate epidermal growth factor …

PKMYT1 is a regulator of CDK1 phosphorylation and is a compelling therapeutic target for
the treatment of certain types of DNA damage response cancers due to its established …

Negative allosteric modulation of GluN2B subunit-containing NMDA receptors prevents
overstimulation, resulting in neuroprotective effects. Since the phenol of prominent negative …

A variety of N-aryl-1 H-indazoles and benzimidazoles were synthesized from common
arylamino oximes in good to excellent yields. The product selectivity depends upon the base …

Polar molecular surface area provides a valuable metric when optimizing properties as
varied as membrane permeability and efflux susceptibility. The EPSA method to measure …