The retinoblastoma tumor suppressor (RB) and its related family members p107 and p130
regulate cell proliferation through the transcriptional repression of genes involved in cellular …

The E2F transcription factor family, whose members are encoded by the E2F1-E2F8 genes,
plays pivotal roles in the cell cycle, apoptosis, metabolism, stemness, metastasis, aging …

Insulin signaling plays key roles in development, growth and metabolism through dynamic
control of glucose uptake, global protein translation and transcriptional regulation. Altered …

Retinoblastoma tumor suppressor proteins regulate the key transition from G1 to S phase of
the cell cycle. The mammalian Rb family comprises Rb, p107, and p130, with overlapping …

RBf2 is a recently evolved retinoblastoma family member in Drosophila that differs from
RBf1, especially in the C-terminus. To investigate whether the unique features of RBf2 …

The retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events
including cell cycle, senescence, and differentiation. The activity and stability of these …

The retinoblastoma (RB) tumor suppressor and related family of proteins play critical roles in
development through their regulation of genes involved in cell fate. Multiple regulatory …

In addition to their canonical roles in the cell cycle, RB family proteins regulate numerous
developmental pathways, although the mechanisms remain obscure. We found that …

The RB tumor suppressor, a regulator of the cell cycle, apoptosis, senescence, and
differentiation, is frequently mutated in human cancers. We recently described an …

The E2F family of transcription factors contributes to oncogenesis through activation of
multiple genes involved in cellular proliferation, a process that is opposed by the …