Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune
cell types and are generally categorized into either of two functionally contrasting subtypes …

Cancer cells characteristically consume glucose through Warburg metabolism, a process
that forms the basis of tumour imaging by positron emission tomography (PET). Tumour …

Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

The growing field of immune metabolism has revealed promising indications for metabolic
targets to modulate anti-cancer immunity. Combination therapies involving metabolic …

Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …