To date, small molecules and macromolecules, including antibodies, have been the most
pursued substances in drug screening and development efforts. Despite numerous …

Unfolded states of proteins and native states of intrinsically disordered proteins (IDPs)
populate heterogeneous conformational ensembles in solution. The average sizes of these …

Single-molecule methods have matured into central tools for studies in biology. Foerster
resonance energy transfer (FRET) techniques, in particular, have been widely applied to …

In this work we have reported the controlled synthesis of gold nanoparticles into the surface
cavities of P123 micellar assemblies together with the fluorescent dye molecules and …

Analysis of protein dynamics using single-molecule fluorescence resonance energy transfer
(smFRET) is widely used to understand the structure and function of proteins. Nonetheless …

A method was developed to monitor dynamic changes in protein structure and interfacial
behavior on surfaces by single-molecule Förster resonance energy transfer. This method …

Strain-promoted alkyne–nitrone cycloadditon (SPANC) was optimized as a versatile strategy
for dual functionalization of peptides and proteins. The usefulness of the dual labeling …

Characterization of the amyloidogenic Parkinson's disease protein α-synuclein (αS) has
proven difficult due to its structural plasticity. Here, we present a number of complementary …

The yellow polyphenolic pigment curcumin has many medicinal and therapeutic properties.
However, the lack of bioavailability prevents its widespread use as a drug. On the other …

A reliable, scalable, cost-effective, and chromatography-free synthesis of 4-azido-l-
phenylalanine beginning from l-phenylalanine is described. Investigations into the safety of …