In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

Eosinophils play a homeostatic role in the body's immune responses. These cells are
involved in combating some parasitic, bacterial, and viral infections and certain cancers and …

Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions
in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours …

The burden of heart failure (HF), developing after myocardial infarction MI, still represents a
major issue in clinical practice. Failure of appropriate resolution of inflammation during post …

Severe asthma imposes a significant burden on patients, families and healthcare systems.
Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care …

Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …

Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the
lung, often with a sudden onset after 5–7 days of stable disease. Efforts to modulate this …

In the past decade, single-cell transcriptomics has helped to uncover new cell types and
states and led to the construction of a cellular compendium of health and disease. Despite …