The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

A series of N-alkyl or aryl substituted isoindigo derivatives have been synthesized and their
anti-proliferative activity was evaluated by Sulforhodamine B (SRB) assay. Some of the …

Glioblastoma multiforme (GBM) is recognized as a most aggressive brain cancer with the
worst prognosis and survival time. Owing to the anatomic location of gliomas, surgically …

Compound 5p is a 4β-N-substituted podophyllotoxin derivative, which exhibited potent
activity toward drug-resistant K562/A02 cells and decreased MDR-1 mRNA expression …

Abstract p-Terphenyls consisting of a C-18 tricyclic or polycyclic C-18 aromatic skeleton,
have diverse structures because of the variation of the middle ring and the connections …

Abstract Terphenyllin (1), a naturally abundant p-terphenyl metabolite, was isolated from the
coral derived fungus Aspergillus candidus together with four natural analogues 2–5. To …

Fungi from the genus Thelephora have been exploited to identify bioactive compounds. The
main natural products characterized are para-terphenyl derivatives, chiefly represented by …

Cardamonin is a natural chalcone that has been shown to exhibit high anticancer activity. In
an attempt to discover analogues of cardamonin with enhanced anticancer activity, 19 …

The analysis of genome sequence indicated that Streptomyces sp. LZ35 has the potential of
producing many types of secondary metabolites, including p-terphenyls and geldanamycins …