Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

Osteoarthritis (OA) has long been considered the unique consequence of a wear and tear
process leading to cartilage degradation. Indeed, it is true that excessive mechanical stress …

Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally
affects individuals with obesity. The mechanisms by which obesity leads to the onset and …

Osteoarthritis (OA) may result from intrinsic inflammation related to metabolic disturbance.
Obesity-associated inflammation is triggered by lipopolysaccharide (LPS) derived from the …

Obesity, and associated metabolic syndrome, have been identified as primary risk factors for
the development of knee osteoarthritis (OA), representing nearly 60% of the OA patient …

Gut microbiota is key to human health and disease. Convincing studies have demonstrated
that dysbiosis in the commensal gut microbiota is associated with intestinal and extra …

Obesity is a well-known primary risk factor for osteoarthritis (OA). In recent decades, the
biomechanics-based theoretical paradigm for the pathogenesis of obesity-associated OA …

Objectives Epidemiological and experimental studies have established obesity to be an
important risk factor for osteoarthritis (OA), however, the mechanisms underlying this link …

Chemokines are pivotal players in instigation and perpetuation of synovitis through
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …