Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …

Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

Recent studies have deepened our understanding of multiple mechanisms by which
extracellular matrix (ECM) molecules regulate various aspects of synaptic plasticity and …

Background Depression is a recurrent and devastating mental disease that is highly
prevalent worldwide. Prolonged exposure to stressful events or a stressful environment is …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. Although ROS are essential participants in cell signaling and …

Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

Cortical spreading depression (CSD) is a propagating wave of neuronal and glial
depolarization and has been implicated in disorders of neurovascular regulation such as …