The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …

The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …

The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp) and ABCG2 are
multidrug transporters that confer drug resistance to numerous anti-cancer therapeutics in …

As a result of the biological activities of natural flavonoids, several synthetic strategies
aiming to obtain analogues with improved potency and/or pharmacokinetic profile have …

Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy
success. Numerous mechanisms are behind the MDR phenomenon wherein the …

ATP-binding cassette (ABC) transporters are pivotal for cell detoxification and survival.
Overexpression of ABC transporter in tumor cells lead to chemoresistance through the efflux …

Breast cancer is one of the most prevalent malignant diseases, and one of the main causes
of mortality among women across the world. Despite advances in chemotherapy, drug …

ABCB1 and ABCG2 are the important ATP-binding cassette (ABC) transporters associated
with multidrug resistance (MDR). Herein, we designed a series of imidazo [1, 2-a] pyridine …

Breast cancer (BC) is a common malignancy in women, with hormone receptor (HR)-positive
subtype responsible for approximately 70% of cases. Currently, patients with metastatic HR …

Chemotherapy is the mainstay in the treatment of breast cancer. However, many drugs that
are commonly used in clinical practice have a high incidence of side effects and multidrug …