The immune system is an evolutionary hallmark of higher organisms that defends the host
against invading pathogens and exogenous infections. This defense includes the …

Abstract Severe Acute Respiratory Syndrome–Coronavirus-2 is responsible for the current
pandemic that has led to more than 10 million confirmed cases of Coronavirus Disease-19 …

Nonsteroidal anti-inflammatory drugs are among the most commonly administered drugs in
the perioperative period due to their prominent role in pain management. However, they …

Background Sepsis is a serious global health issue and a major cause of death and
disability. The availability of a simple, community-based preventive strategy could …

Antagonists of the renin-angiotensin-aldosterone system (RAAS), including ACEIs
(angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers), may …

Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is
associated with mortality. This thrombocytopenia is characteristic of disseminated …

Platelet activation plays an important role in the development of sepsis. During sepsis,
platelet activation leads to endothelial cell injury and promotes neutrophil extracellular trap …

Patients with severe infections and a pre-existing indication for antithrombotic therapy, ie
antiplatelet agents, anticoagulant drugs, or their combinations, require integrated clinical …

Recent studies have revealed that tumor-associated macrophages are the most abundant
stromal cells in the tumor microenvironment and play an important role in tumor initiation …

C-type lectin-like receptor 2 (CLEC-2) is a platelet-activated receptor expressed on the
surface of platelet membranes. Soluble CLEC-2 (sCLEC-2) has been receiving attention as …