Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is
largely based on genome-wide association study (GWAS) analysis of common SNPs …

Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand
for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and …

Background Familial hypercholesterolaemia is a common autosomal-dominant disorder
caused by mutations in three known genes. DNA-based cascade testing is recommended by …

Apolipoprotein C1 (apoC1), the smallest of all apolipoproteins, participates in lipid transport
and metabolism. In humans, APOC1 gene is in linkage disequilibrium with APOE gene on …

For a long time, high-density lipoprotein cholesterol (HDL-C) has been regarded as a
cardiovascular disease (CVD) protective factor. Recently, several epidemiological studies …

Sequence variants affecting blood lipids and coronary artery disease (CAD) may enhance
understanding of the atherogenicity of lipid fractions. Using a large resource of whole …

Susceptibility to the growing global public health problem of cardiovascular disease is
associated with levels of plasma lipids and lipoproteins. Several experimental strategies …

Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …