Tim R. Mosmann and Subash Sad he T helper 1 (Thl) and Th2 patterns of cytokine
production were originally described among mouse CD4'T-cell clone@ and later among …

In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+
helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation …

Recently, there have been several reports demonstrating improvements in the flow
cytometric detection of intracellular cytokines. These advances, although significant, have …

One of the important mechanisms of immunosuppression in the tumor-bearing status has
been attributed to the down-modulation of the CD3 ζ chain and its associated signaling …

Commitment of T helper 1 (Th1) or Th2 populations developing during an immune response
to a pathogen, or an inappropriate immune response to an allergen or autoantigen, may …

Human leukocytes express cannabinoid (CB) receptors, suggesting a role for both
endogenous ligands and Δ9-tetrahydrocannabinol (THC) as immune modulators. To …

Objective: To characterize changes of Th1/Th2 cytokine production by peripheral blood
mononuclear cells (PBMC) that occur during the course of HIV infection by cytoplasmic …

Interleukin-12 (IL-12) induces differentiation of T helper 1 (Th1) cells, primarily through its
ability to prime T cells for high interferon-gamma (IFN-gamma) production. We now report …

We have recently described a highly sensitive flow cytometric technique, based on the ability
to detect single cell expression of cytokines, to simultaneously quantitate and phenotypically …

Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine produced primarily by antigen-
presenting cells (monocytes, macrophages, dendritic cells, and B cells). Its production is …