The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Cysteine residues are concentrated at key functional sites within proteins, performing
diverse roles in metal binding, catalysis, and redox chemistry. Chemoproteomic platforms to …

Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Abstract Iron–sulfur (Fe–S) clusters are ubiquitous metallocofactors involved in redox
chemistry, radical generation and gene regulation. Common methods to monitor Fe–S …

Chemoproteomics has enabled the rapid and proteome‐wide discovery of functional, redox‐
sensitive, and ligandable cysteine residues. Despite widespread adoption and considerable …

Proteinaceous cysteines function as essential sensors of cellular redox state. Consequently,
defining the cysteine redoxome is a key challenge for functional proteomic studies. While …

Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies
on stored resources and is reactivated to drive germination when the external conditions are …

Unlike most other tissues, the colon epithelium is exposed to high levels of H 2 S derived
from gut microbial metabolism. H 2 S is a signaling molecule that modulates various …

Reactive oxygen species (ROS) can modulate protein function through cysteine oxidation.
Identifying protein targets of ROS can provide insight into uncharacterized ROS-regulated …

Cysteine modifications emerge as important players in cellular signaling and homeostasis.
Here, we present a chemical proteomics strategy for quantitative analysis of reversibly …