Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious
molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is …

Background The search for bioactive molecules from medicinal plants of the family
Asteraceae has been one of the targets in various phytochemical and pharmacological …

Islet inflammation is an important etiopathology of type 2 diabetes; however, the underlying
mechanisms are not well defined. Using complementary experimental models, we …

Diabetes is a metabolic disease characterized by high blood glucose levels. With economic
development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it …

The pharmacological potential of nanotechnology, especially in drug delivery and
bioengineering, has developed rapidly in recent decades. Ion channels, which are easily …

Five years after the launch of the Disease Models & Mechanisms (DMM) Special Issue on
zebrafish as a disease model, the field has progressed significantly. Zebrafish have been …

Persistent endoplasmic reticulum (ER) stress induces islet inflammation and β cell loss. How
islet inflammation contributes to β cell loss remains uncertain. We have reported previously …

Purpose Wedelolactone, a chemical compound extracted from Wedelia calendulacea or
Eclipta alba, has been reported to regulate key steps in inflammation. However, the effects of …

Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a vital role in the innate
immune system. To observe the innate immune response in vivo, several transgenic …

Diabetes mellitus is a complex and multifactorial disease with a global prevalence that
exceeds 425 million people. Type 2 diabetes mellitus (T2DM) is characterized by a state of …