Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however …

Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

NOTE: In the version of this Review initially published, an author (B. Martin Hallberg) was left
off of the author list. This information has been added to the HTML and PDF versions of the …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Background Tuberculosis still remains one of the largest killer infectious diseases,
warranting the identification of newer targets and drugs. Identification and validation of …

Selecting the best targets is a key challenge for drug discovery, and achieving this
effectively, efficiently and systematically is particularly important for prioritizing candidates …

Several years ago small molecular weight protein–protein interaction (PPI) antagonists were
considered as the Mount Everest in drug discovery and generally regarded as too difficult to …

Abstract Background The Apicomplexa constitute an evolutionarily divergent phylum of
protozoan pathogens responsible for widespread parasitic diseases such as malaria and …

As an important aspect of computer-aided drug design, structure-based drug design brought
a new horizon to pharmaceutical development. This in silico method permeates all aspects …

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites.
Many apicomplexan protein kinases are substantially different from their mammalian …