Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer
Anticancer drugs are not purely effective because of their toxicity, side effects, high cost,
inaccessibility, and associated resistance. On the other hand, cancer is a complex public …
inaccessibility, and associated resistance. On the other hand, cancer is a complex public …
Therapeutic potential of jasmonic acid and its derivatives
I Jarocka-Karpowicz, A Markowska - International Journal of Molecular …, 2021 - mdpi.com
A modern method of therapeutic use of natural compounds that would protect the body are
jasmonates. The main representatives of jasmonate compounds include jasmonic acid and …
jasmonates. The main representatives of jasmonate compounds include jasmonic acid and …
A novel microcrystalline BAY-876 formulation achieves long-acting antitumor activity against aerobic glycolysis and proliferation of hepatocellular carcinoma
H Yang, MZ Zhang, H Sun, Y Chai, X Li, Q Jiang… - Frontiers in …, 2021 - frontiersin.org
BAY-876 is an effective antagonist of the Glucose transporter type 1 (GLUT1) receptor, a
mediator of aerobic glycolysis, a biological process considered a hallmark of hepatocellular …
mediator of aerobic glycolysis, a biological process considered a hallmark of hepatocellular …
Orchestral role of lipid metabolic reprogramming in T-cell malignancy
The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …
Glutor, a glucose transporter inhibitor, exerts antineoplastic action on tumor cells of thymic origin: Implication of modulated metabolism, survival, oxidative stress …
Neoplastic cells overexpress glucose transporters (GLUT), particularly GLUT1 and GLUT3,
to support altered metabolism. Hence, novel strategies are being explored to effectively …
to support altered metabolism. Hence, novel strategies are being explored to effectively …
Natural products targeting glycolytic signaling pathways-an updated review on anti-cancer therapy
Y Cui, C Li, F Sang, W Cao, Z Qin… - Frontiers in …, 2022 - frontiersin.org
Glycolysis is a complex metabolic process that occurs to convert glucose into pyruvate to
produce energy for living cells. Normal cells oxidized pyruvate into adenosine triphosphate …
produce energy for living cells. Normal cells oxidized pyruvate into adenosine triphosphate …
Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy
L Zhang, N Chang, J Liu, Z Liu, Y Wu, L Sui… - Frontiers in …, 2022 - frontiersin.org
Hematological malignancies are one of the most lethal illnesses that seriously threaten
human life and health. Lipids are important constituents of various biological membranes …
human life and health. Lipids are important constituents of various biological membranes …
[HTML][HTML] EZH2 activates Wnt/β-catenin signaling in human uterine fibroids, which is inhibited by the natural compound methyl jasmonate
Objective To investigate the link between EZH2 and Wnt/β-catenin signaling and its role in
uterine fibroids (UFs) pathogenesis and explore the potential effect of natural compound …
uterine fibroids (UFs) pathogenesis and explore the potential effect of natural compound …
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-associated death in the West. This type of cancer has a very poor prognosis notably …
G Yang, Y Hori, A Couvineau - … mitochondrial dynamics and …, 2023 - books.google.com
Pancreatic cancers widely represented (> 90%) by pancreatic ductal adenocarcinoma
(PDAC) are the most lethal human digestive cancer with a very poor 5-year-survival rate …
(PDAC) are the most lethal human digestive cancer with a very poor 5-year-survival rate …
[HTML][HTML] Diagnostic test of dynamic computed tomography in early gastrointestinal lymphoma and precancerous lesions
J Chen, Y Zhong, X Zeng, C Huang… - Translational Cancer …, 2022 - ncbi.nlm.nih.gov
Background In recent years, with the development of imaging technology, the accurate
diagnosis of precancerous lesions of digestive system and early lymphoma has attracted …
diagnosis of precancerous lesions of digestive system and early lymphoma has attracted …